A cure for cancer is also in research. But to do so, it is necessary to overcome many challenges, including: funding, awareness, regulation, and encouragement of scientific production. The researchers attribute the notable advances to advances in areas such as cancer research, prevention, detection, diagnosis, and treatment. In addition, they highlight the revolution that has taken place in immune therapies, which, together with chemotherapy and radiotherapy, contribute to extending patients' lives.
Currently, Brazil participates in only 2% of the studies, globally. Adding the other countries together, Latin America participates in only 5% of ongoing oncology trials, and 90% of clinical trials in the region are funded by the pharmaceutical industry. The industry carries out important research, but it is not enough, in addition to the fact that many of them have objectives that are different from those that we really need to carry out.
Clinical trials can help to make better use of medical treatment, maintaining the integrity and quality of life of patients during this sensitive period. Without this qualified participation, we risk seeing new drugs being introduced in our country without oncologists having any experience of the impacts on their effective use.
Conducted in a laboratory. Before being tested on humans, the drug undergoes several phases of study where its efficacy and safety are evaluated.
The safety of the drug in humans is evaluated, so few patients, generally healthy, participate in the highly monitored studies (it takes a few months).
The safety of the drug is re-evaluated and the first evaluation of the efficacy of the drug in the fight against the disease is also carried out. It involves a larger population that has the disease. It lasts, on average, 2 to 3 years
The studies are larger and more complex to confirm efficacy, tolerability, and safety of the investigational drug. Therefore, it is performed with a much larger group of patients. The drug is compared with standard therapy. At this stage, the necessary information is obtained to prepare the drug label and package insert. It can extend from 2 to 10 years.
Performed after the drug has been registered and used in the clinical routine, that is, it is already marketed. These are observational studies to obtain various information, such as the appearance of new adverse reactions or confirmation of already known reactions. It involves thousands of patients.
In yet another initiative to raise awareness about Clinical Research, the Cura Project Institute presents the Walking with Confidence Campaign: Understanding Clinical Research, an action that aims to expand knowledge about the importance of clinical research. The campaign was structured with the curatorship of oncologists and researchers, providing information in a simplified and easy-to-understand language.
Primary objectives: To evaluate in a phase III randomized clinical trial the comparison between an anthracycline-initiated neoadjuvant chemotherapy (AC-T) versus a taxane-initiated (T-AC) regimen in patients with locally advanced HER2 breast cancer
Primary objectives: To compare overall survival for individuals treated with docetaxel versus individuals treated with docetaxel plus Radio-223.
Primary objectives: To demonstrate the superiority of volrustomig over placebo by evaluating PFS in participants with high PD-L1 expression.
Primary objectives: To evaluate the pCR rate in participants with HER2-positive early breast cancer selected for high dependence on the HER2 pathway and treated with neoadjuvant PHESGO without chemotherapy; who demonstrate a favorable PET-CT response after the third cycle of therapy.
Describe the epidemiological characteristics and prognostic factors for disease-free survival of patients with CC with and without HIV infection.
Primary objectives: To describe epidemiological characteristics, molecular profile, treatment patterns, and outcomes of endometrial cancer in a Brazilian population
Primary objectives: To evaluate the safety profile, including dose modifications, of nirparib in patients with advanced ovarian cancer in response after platinum-based first-line chemotherapy treated in a real-world environment within the EAP.
Informe-se se tem algum estudo clínico aberto que contemple as características da sua doença. Cada estudo possui critérios de inclusão diferentes. Converse com seu médico para saber se, no momento, há algum tratamento disponível através de estudo clínico que poderia ajudar no seu caso. Existem algumas plataformas, sites e perfis de divulgação de pesquisas. O @projetocura, o @lacogcancerresearch e o @pesquisaclinicacancer sempre divulgam estudos abertos.
Get in touch and the medical researchers will assess whether your disease is compatible with the research that will be carried out, and all the risks and benefits of the treatment. If so, you will be informed of all the details and will be part of a treatment group and become a volunteer. Each group receives different treatments, which may include the treatment under investigation (new drug), or standard treatment, or even the receipt of a placebo (product without active medication, without harm to the volunteer).
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